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Numbering & Regions

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Region Sequence Details
Regions Definition:
Region Sequence Fragment Residues Length
LFR1
ESALTQPASVSGSPGQSITVSC
1 - 22 22
CDR-L1
AGHTSDVADSNSIS
23 - 36 14
LFR2
WFQQHPDKAPKLLIY
37 - 51 15
CDR-L2
AVTFRPS
52 - 58 7
LFR3
GIPLRFSGSKSGNTASLTISGLLPDDEADYFC
59 - 90 32
CDR-L3
MSYLSDASFV
91 - 100 10
LFR4
FGSGTKVTVLRQP
101 - 113 13
Tail
KANPTVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADGSPVEAGVETTKPSKQSN
NKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS
114 - 216 103
216
Region Sequence Fragment Residues Length
LFR1
ESALTQPASVSGSPGQSITVSC
1 - 22 22
CDR-L1
AGHTSDVADSNSIS
23 - 36 14
LFR2
WFQQHPDKAPKLLIY
37 - 51 15
CDR-L2
AVTFRPS
52 - 58 7
LFR3
GIPLRFSGSKSGNTASLTISGLLPDDEADYFC
59 - 90 32
CDR-L3
MSYLSDASFV
91 - 100 10
LFR4
FGSGTKVTVLRQP
101 - 113 13
Tail
KANPTVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADGSPVEAGVETTKPSKQSN
NKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS
114 - 216 103
216
Region Sequence Fragment Residues Length
LFR1
ESALTQPASVSGSPGQSITVSC
1 - 22 22
CDR-L1
AGHTSDVADSNSIS
23 - 36 14
LFR2
WFQQHPDKAPKLLIY
37 - 51 15
CDR-L2
AVTFRPS
52 - 58 7
LFR3
GIPLRFSGSKSGNTASLTISGLLPDDEADYFC
59 - 90 32
CDR-L3
MSYLSDASFV
91 - 100 10
LFR4
FGSGTKVTVLRQP
101 - 113 13
Tail
KANPTVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADGSPVEAGVETTKPSKQSN
NKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS
114 - 216 103
216
Region Sequence Fragment Residues Length
LFR1
ESALTQPASVSGSPGQSITVSCAGHTSD
1 - 28 28
CDR-L1
VADSNSISWF
29 - 38 10
LFR2
QQHPDKAPK
39 - 47 9
CDR-L2
LLIYAVTFRP
48 - 57 10
LFR3
SGIPLRFSGSKSGNTASLTISGLLPDDEADYFC
58 - 90 33
CDR-L3
MSYLSDASF
91 - 99 9
LFR4
VFGSGTKVTVLRQP
100 - 113 14
Tail
KANPTVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADGSPVEAGVETTKPSKQSN
NKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS
114 - 216 103
216
Region Sequence Fragment Residues Length
LFR1
ESALTQPASVSGSPGQSITVSCAGH
1 - 25 25
CDR-L1
TSDVADSNS
26 - 34 9
LFR2
ISWFQQHPDKAPKLLIY
35 - 51 17
CDR-L2
AV
52 - 53 2
LFR3
TFRPSGIPLRFSGSKSGNTASLTISGLLPDDEADYFC
54 - 90 37
CDR-L3
MSYLSDASFV
91 - 100 10
LFR4
FGSGTKVTVLRQP
101 - 113 13
Tail
KANPTVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADGSPVEAGVETTKPSKQSN
NKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS
114 - 216 103
216
Region Definition Sequence Fragment Residues Length
LFR1 Chothia
ESALTQPASVSGSPGQSITVSC------
1 - 22 22
AbM
ESALTQPASVSGSPGQSITVSC------
1 - 22 22
Kabat
ESALTQPASVSGSPGQSITVSC------
1 - 22 22
Contact
ESALTQPASVSGSPGQSITVSCAGHTSD
1 - 28 28
IMGT
ESALTQPASVSGSPGQSITVSCAGH---
1 - 25 25
CDR-L1 Chothia
AGHTSDVADSNSIS--
23 - 36 14
AbM
AGHTSDVADSNSIS--
23 - 36 14
Kabat
AGHTSDVADSNSIS--
23 - 36 14
Contact
------VADSNSISWF
29 - 38 10
IMGT
---TSDVADSNS----
26 - 34 9
LFR2 Chothia
--WFQQHPDKAPKLLIY
37 - 51 15
AbM
--WFQQHPDKAPKLLIY
37 - 51 15
Kabat
--WFQQHPDKAPKLLIY
37 - 51 15
Contact
----QQHPDKAPK----
39 - 47 9
IMGT
ISWFQQHPDKAPKLLIY
35 - 51 17
CDR-L2 Chothia
----AVTFRPS
52 - 58 7
AbM
----AVTFRPS
52 - 58 7
Kabat
----AVTFRPS
52 - 58 7
Contact
LLIYAVTFRP-
48 - 57 10
IMGT
----AV-----
52 - 53 2
LFR3 Chothia
-----GIPLRFSGSKSGNTASLTISGLLPDDEADYFC
59 - 90 32
AbM
-----GIPLRFSGSKSGNTASLTISGLLPDDEADYFC
59 - 90 32
Kabat
-----GIPLRFSGSKSGNTASLTISGLLPDDEADYFC
59 - 90 32
Contact
----SGIPLRFSGSKSGNTASLTISGLLPDDEADYFC
58 - 90 33
IMGT
TFRPSGIPLRFSGSKSGNTASLTISGLLPDDEADYFC
54 - 90 37
CDR-L3 Chothia
MSYLSDASFV
91 - 100 10
AbM
MSYLSDASFV
91 - 100 10
Kabat
MSYLSDASFV
91 - 100 10
Contact
MSYLSDASF-
91 - 99 9
IMGT
MSYLSDASFV
91 - 100 10
LFR4 Chothia
-FGSGTKVTVLRQP
101 - 113 13
AbM
-FGSGTKVTVLRQP
101 - 113 13
Kabat
-FGSGTKVTVLRQP
101 - 113 13
Contact
VFGSGTKVTVLRQP
100 - 113 14
IMGT
-FGSGTKVTVLRQP
101 - 113 13
Humanness

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Accession & Annotations
Accession 1mcw_W
Source PDB  1mcw  Submitted 09-MAY-1989  Updated 25-DEC-2019
Name
THREE-DIMENSIONAL STRUCTURE OF A HYBRID LIGHT CHAIN DIMER. PROTEIN ENGINEERING OF A BINDING CAVITY
Organism
Homo sapiens
Human Subgroup Lambda Light chain subgroup II
Chain Type Light
Pairing None
Identical Protein Sequences None
References
ELY R., HERRON N., EDMUNDSON B.
'THREE-DIMENSIONAL STRUCTURE OF A HYBRID LIGHT CHAIN DIMER: PROTEIN ENGINEERING OF A BINDING CAVITY.'
MOL.IMMUNOL. V. 27 101 1990 ISSN 0161-5890
Sequences
Amino Acid Sequence:
ESALTQPASVSGSPGQSITVSCAGHTSDVADSNSISWFQQHPDKAPKLLIYAVTFRPSGI
PLRFSGSKSGNTASLTISGLLPDDEADYFCMSYLSDASFVFGSGTKVTVLRQPKANPTVT
LFPPSSEELQANKATLVCLISDFYPGAVTVAWKADGSPVEAGVETTKPSKQSNNKYAASS
YLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS

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Germline Tools
Data Source:
Data Source V D J Exclude if warnings
NCBI Germline
V-BASE
Alignment settings:
Rank alignments by
Exclude identical hits
Search settings:
V-segment score threshold
D-segment score threshold
J-segment score threshold
Gaps:
Gap penalty

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No experimental structure

abYmod homology modelling

Note: following issues may prevent a model being generated:


Homology modelling failed because :-



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Chains
No Chain
All Heavy
All HFR
All CDR-H
HFR1
CDR-H1
HFR2
CDR-H2
HFR3
CDR-H3
HFR4
Other Heavy
1mcw_W
All Light
All LFR
All CDR-L
LFR1
CDR-L1
LFR2
CDR-L2
LFR3
CDR-L3
LFR4
Other Light
Colours
Labels
On
Off
Atoms
Main chain
All
Style
Wireframe
Ball and Stick
Spacefill
Cartoon
Backbone
Reset
Black
Reset
White

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