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Numbering & Regions

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Region Sequence Details
Regions Definition:
Region Sequence Fragment Residues Length
HFR1
DVQFQESGPSLVKPSQTLSLTCSVT
1 - 25 25
CDR-H1
GDSITSD
26 - 32 7
HFR2
HWSWIRKFPGNRLEYMGYV
33 - 51 19
CDR-H2
SYSGN
52 - 56 5
HFR3
TFYNPSLKSRISITRDTSKNQYYLDLNSVTTEDTATYYCAN
57 - 97 41
CDR-H3
WDGDY
98 - 102 5
HFR4
WGQGTLVTVSA
103 - 113 11
Tail
AKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSD
LYTLSSSVTVPSSTWPSQTVTCNVAHPASSTKVDKKIVPRDCGSHHHHHH
114 - 223 110
223
Region Sequence Fragment Residues Length
HFR1
DVQFQESGPSLVKPSQTLSLTCSVT
1 - 25 25
CDR-H1
GDSITSDHWS
26 - 35 10
HFR2
WIRKFPGNRLEYMG
36 - 49 14
CDR-H2
YVSYSGNTF
50 - 58 9
HFR3
YNPSLKSRISITRDTSKNQYYLDLNSVTTEDTATYYCAN
59 - 97 39
CDR-H3
WDGDY
98 - 102 5
HFR4
WGQGTLVTVSA
103 - 113 11
Tail
AKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSD
LYTLSSSVTVPSSTWPSQTVTCNVAHPASSTKVDKKIVPRDCGSHHHHHH
114 - 223 110
223
Region Sequence Fragment Residues Length
HFR1
DVQFQESGPSLVKPSQTLSLTCSVTGDSIT
1 - 30 30
CDR-H1
SDHWS
31 - 35 5
HFR2
WIRKFPGNRLEYMG
36 - 49 14
CDR-H2
YVSYSGNTFYNPSLKS
50 - 65 16
HFR3
RISITRDTSKNQYYLDLNSVTTEDTATYYCAN
66 - 97 32
CDR-H3
WDGDY
98 - 102 5
HFR4
WGQGTLVTVSA
103 - 113 11
Tail
AKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSD
LYTLSSSVTVPSSTWPSQTVTCNVAHPASSTKVDKKIVPRDCGSHHHHHH
114 - 223 110
223
Region Sequence Fragment Residues Length
HFR1
DVQFQESGPSLVKPSQTLSLTCSVTGDSI
1 - 29 29
CDR-H1
TSDHWS
30 - 35 6
HFR2
WIRKFPGNRLE
36 - 46 11
CDR-H2
YMGYVSYSGNTF
47 - 58 12
HFR3
YNPSLKSRISITRDTSKNQYYLDLNSVTTEDTATYYC
59 - 95 37
CDR-H3
ANWDGD
96 - 101 6
HFR4
YWGQGTLVTVSA
102 - 113 12
Tail
AKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSD
LYTLSSSVTVPSSTWPSQTVTCNVAHPASSTKVDKKIVPRDCGSHHHHHH
114 - 223 110
223
Region Sequence Fragment Residues Length
HFR1
DVQFQESGPSLVKPSQTLSLTCSVT
1 - 25 25
CDR-H1
GDSITSDH
26 - 33 8
HFR2
WSWIRKFPGNRLEYMGY
34 - 50 17
CDR-H2
VSYSGNT
51 - 57 7
HFR3
FYNPSLKSRISITRDTSKNQYYLDLNSVTTEDTATYYC
58 - 95 38
CDR-H3
ANWDGDY
96 - 102 7
HFR4
WGQGTLVTVSA
103 - 113 11
Tail
AKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSD
LYTLSSSVTVPSSTWPSQTVTCNVAHPASSTKVDKKIVPRDCGSHHHHHH
114 - 223 110
223
Region Definition Sequence Fragment Residues Length
HFR1 Chothia
DVQFQESGPSLVKPSQTLSLTCSVT-----
1 - 25 25
AbM
DVQFQESGPSLVKPSQTLSLTCSVT-----
1 - 25 25
Kabat
DVQFQESGPSLVKPSQTLSLTCSVTGDSIT
1 - 30 30
Contact
DVQFQESGPSLVKPSQTLSLTCSVTGDSI-
1 - 29 29
IMGT
DVQFQESGPSLVKPSQTLSLTCSVT-----
1 - 25 25
CDR-H1 Chothia
GDSITSD---
26 - 32 7
AbM
GDSITSDHWS
26 - 35 10
Kabat
-----SDHWS
31 - 35 5
Contact
----TSDHWS
30 - 35 6
IMGT
GDSITSDH--
26 - 33 8
HFR2 Chothia
HWSWIRKFPGNRLEYMGYV
33 - 51 19
AbM
---WIRKFPGNRLEYMG--
36 - 49 14
Kabat
---WIRKFPGNRLEYMG--
36 - 49 14
Contact
---WIRKFPGNRLE-----
36 - 46 11
IMGT
-WSWIRKFPGNRLEYMGY-
34 - 50 17
CDR-H2 Chothia
-----SYSGN---------
52 - 56 5
AbM
---YVSYSGNTF-------
50 - 58 9
Kabat
---YVSYSGNTFYNPSLKS
50 - 65 16
Contact
YMGYVSYSGNTF-------
47 - 58 12
IMGT
----VSYSGNT--------
51 - 57 7
HFR3 Chothia
TFYNPSLKSRISITRDTSKNQYYLDLNSVTTEDTATYYCAN
57 - 97 41
AbM
--YNPSLKSRISITRDTSKNQYYLDLNSVTTEDTATYYCAN
59 - 97 39
Kabat
---------RISITRDTSKNQYYLDLNSVTTEDTATYYCAN
66 - 97 32
Contact
--YNPSLKSRISITRDTSKNQYYLDLNSVTTEDTATYYC--
59 - 95 37
IMGT
-FYNPSLKSRISITRDTSKNQYYLDLNSVTTEDTATYYC--
58 - 95 38
CDR-H3 Chothia
--WDGDY
98 - 102 5
AbM
--WDGDY
98 - 102 5
Kabat
--WDGDY
98 - 102 5
Contact
ANWDGD-
96 - 101 6
IMGT
ANWDGDY
96 - 102 7
HFR4 Chothia
-WGQGTLVTVSA
103 - 113 11
AbM
-WGQGTLVTVSA
103 - 113 11
Kabat
-WGQGTLVTVSA
103 - 113 11
Contact
YWGQGTLVTVSA
102 - 113 12
IMGT
-WGQGTLVTVSA
103 - 113 11
Humanness

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Accession & Annotations
Accession 6p4b_B
Source PDB  6p4b  Submitted 27-MAY-2019  Updated 16-DEC-2020
Name
HYHEL10 FAB VARIANT HYHEL10-4X (HEAVY CHAIN MUTATIONS L4F, Y33H, S56N, AND Y58F) BOUND TO HEN EGG LYSOZYME VARIANT HEL2X-FLEX (MUTATIONS R21Q, R73E, C76S, AND C94S)
Organism
Mus musculus
Chain Type Heavy
Pairing 6p4b_A
Identical Protein Sequences PDB: 6p4b_H 6p4c_H
References
BURNETT L., SCHOFIELD P., LANGLEY B., JACKSON J., BOURNE K., WILSON E., POREBSKI T., BUCKLE M., BRINK R., GOODNOW C., CHRIST D.
'CONFORMATIONAL DIVERSITY FACILITATES ANTIBODY MUTATION TRAJECTORIES AND DISCRIMINATION BETWEEN FOREIGN AND SELF-ANTIGENS.'
PROC.NATL.ACAD.SCI.USA V. 117 22341 2020 ESSN 1091-6490
Sequences
Amino Acid Sequence:
DVQFQESGPSLVKPSQTLSLTCSVTGDSITSDHWSWIRKFPGNRLEYMGYVSYSGNTFYN
PSLKSRISITRDTSKNQYYLDLNSVTTEDTATYYCANWDGDYWGQGTLVTVSAAKTTPPS
VYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSS
VTVPSSTWPSQTVTCNVAHPASSTKVDKKIVPRDCGSHHHHHH

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Germline Tools
Data Source:
Data Source V D J Exclude if warnings
NCBI Germline
V-BASE
Alignment settings:
Rank alignments by
Exclude identical hits
Search settings:
V-segment score threshold
D-segment score threshold
J-segment score threshold
Gaps:
Gap penalty

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No experimental structure

abYmod homology modelling

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Chains
6p4b_B
All Heavy
All HFR
All CDR-H
HFR1
CDR-H1
HFR2
CDR-H2
HFR3
CDR-H3
HFR4
Other Heavy
6p4b_A
All Light
All LFR
All CDR-L
LFR1
CDR-L1
LFR2
CDR-L2
LFR3
CDR-L3
LFR4
Other Light
Colours
Labels
On
Off
Atoms
Main chain
All
Style
Wireframe
Ball and Stick
Spacefill
Cartoon
Backbone
Reset
Black
Reset
White

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