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Numbering & Regions

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Region Sequence Details
Regions Definition:
Region Sequence Fragment Residues Length
HFR1
EVQLVESGGDLVKPGGSLKLSCAAS
1 - 25 25
CDR-H1
GFSFSSY
26 - 32 7
HFR2
GMSWVRQTPDKRLEWVATI
33 - 51 19
CDR-H2
SNGGGY
52 - 57 6
HFR3
TYYPDSVKGRFTISRDNAKNTLYLQMSSLKSEDSAMYYCAR
58 - 98 41
CDR-H3
RERYDENGFAY
99 - 109 11
HFR4
WGQGTLVTVSA
110 - 120 11
Tail
AKTTAPSVYPLAPVCGDTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSD
LYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKIEPR
121 - 220 100
220
Region Sequence Fragment Residues Length
HFR1
EVQLVESGGDLVKPGGSLKLSCAAS
1 - 25 25
CDR-H1
GFSFSSYGMS
26 - 35 10
HFR2
WVRQTPDKRLEWVA
36 - 49 14
CDR-H2
TISNGGGYTY
50 - 59 10
HFR3
YPDSVKGRFTISRDNAKNTLYLQMSSLKSEDSAMYYCAR
60 - 98 39
CDR-H3
RERYDENGFAY
99 - 109 11
HFR4
WGQGTLVTVSA
110 - 120 11
Tail
AKTTAPSVYPLAPVCGDTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSD
LYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKIEPR
121 - 220 100
220
Region Sequence Fragment Residues Length
HFR1
EVQLVESGGDLVKPGGSLKLSCAASGFSFS
1 - 30 30
CDR-H1
SYGMS
31 - 35 5
HFR2
WVRQTPDKRLEWVA
36 - 49 14
CDR-H2
TISNGGGYTYYPDSVKG
50 - 66 17
HFR3
RFTISRDNAKNTLYLQMSSLKSEDSAMYYCAR
67 - 98 32
CDR-H3
RERYDENGFAY
99 - 109 11
HFR4
WGQGTLVTVSA
110 - 120 11
Tail
AKTTAPSVYPLAPVCGDTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSD
LYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKIEPR
121 - 220 100
220
Region Sequence Fragment Residues Length
HFR1
EVQLVESGGDLVKPGGSLKLSCAASGFSF
1 - 29 29
CDR-H1
SSYGMS
30 - 35 6
HFR2
WVRQTPDKRLE
36 - 46 11
CDR-H2
WVATISNGGGYTY
47 - 59 13
HFR3
YPDSVKGRFTISRDNAKNTLYLQMSSLKSEDSAMYYC
60 - 96 37
CDR-H3
ARRERYDENGFA
97 - 108 12
HFR4
YWGQGTLVTVSA
109 - 120 12
Tail
AKTTAPSVYPLAPVCGDTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSD
LYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKIEPR
121 - 220 100
220
Region Sequence Fragment Residues Length
HFR1
EVQLVESGGDLVKPGGSLKLSCAAS
1 - 25 25
CDR-H1
GFSFSSYG
26 - 33 8
HFR2
MSWVRQTPDKRLEWVAT
34 - 50 17
CDR-H2
ISNGGGYT
51 - 58 8
HFR3
YYPDSVKGRFTISRDNAKNTLYLQMSSLKSEDSAMYYC
59 - 96 38
CDR-H3
ARRERYDENGFAY
97 - 109 13
HFR4
WGQGTLVTVSA
110 - 120 11
Tail
AKTTAPSVYPLAPVCGDTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSD
LYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKIEPR
121 - 220 100
220
Region Definition Sequence Fragment Residues Length
HFR1 Chothia
EVQLVESGGDLVKPGGSLKLSCAAS-----
1 - 25 25
AbM
EVQLVESGGDLVKPGGSLKLSCAAS-----
1 - 25 25
Kabat
EVQLVESGGDLVKPGGSLKLSCAASGFSFS
1 - 30 30
Contact
EVQLVESGGDLVKPGGSLKLSCAASGFSF-
1 - 29 29
IMGT
EVQLVESGGDLVKPGGSLKLSCAAS-----
1 - 25 25
CDR-H1 Chothia
GFSFSSY---
26 - 32 7
AbM
GFSFSSYGMS
26 - 35 10
Kabat
-----SYGMS
31 - 35 5
Contact
----SSYGMS
30 - 35 6
IMGT
GFSFSSYG--
26 - 33 8
HFR2 Chothia
GMSWVRQTPDKRLEWVATI
33 - 51 19
AbM
---WVRQTPDKRLEWVA--
36 - 49 14
Kabat
---WVRQTPDKRLEWVA--
36 - 49 14
Contact
---WVRQTPDKRLE-----
36 - 46 11
IMGT
-MSWVRQTPDKRLEWVAT-
34 - 50 17
CDR-H2 Chothia
-----SNGGGY---------
52 - 57 6
AbM
---TISNGGGYTY-------
50 - 59 10
Kabat
---TISNGGGYTYYPDSVKG
50 - 66 17
Contact
WVATISNGGGYTY-------
47 - 59 13
IMGT
----ISNGGGYT--------
51 - 58 8
HFR3 Chothia
TYYPDSVKGRFTISRDNAKNTLYLQMSSLKSEDSAMYYCAR
58 - 98 41
AbM
--YPDSVKGRFTISRDNAKNTLYLQMSSLKSEDSAMYYCAR
60 - 98 39
Kabat
---------RFTISRDNAKNTLYLQMSSLKSEDSAMYYCAR
67 - 98 32
Contact
--YPDSVKGRFTISRDNAKNTLYLQMSSLKSEDSAMYYC--
60 - 96 37
IMGT
-YYPDSVKGRFTISRDNAKNTLYLQMSSLKSEDSAMYYC--
59 - 96 38
CDR-H3 Chothia
--RERYDENGFAY
99 - 109 11
AbM
--RERYDENGFAY
99 - 109 11
Kabat
--RERYDENGFAY
99 - 109 11
Contact
ARRERYDENGFA-
97 - 108 12
IMGT
ARRERYDENGFAY
97 - 109 13
HFR4 Chothia
-WGQGTLVTVSA
110 - 120 11
AbM
-WGQGTLVTVSA
110 - 120 11
Kabat
-WGQGTLVTVSA
110 - 120 11
Contact
YWGQGTLVTVSA
109 - 120 12
IMGT
-WGQGTLVTVSA
110 - 120 11
Humanness

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Accession & Annotations
Accession 1hil_B
Source PDB  1hil  Submitted 08-JUL-1992  Updated 24-FEB-2009
Name
STRUCTURAL EVIDENCE FOR INDUCED FIT AS A MECHANISM FOR ANTIGEN-ANTIBODY RECOGNITION
Organism
Mus musculus
Chain Type Heavy
Pairing 1hil_A
Identical Protein Sequences PDB: 1hil_D 1him_L 1him_M 1hin_H 1ifh_H
References
RINI M., SCHULZE-GAHMEN U., WILSON A.
'STRUCTURAL EVIDENCE FOR INDUCED FIT AS A MECHANISM FOR ANTIBODY-ANTIGEN RECOGNITION.'
SCIENCE V. 255 959 1992 ISSN 0036-8075
Sequences
Amino Acid Sequence:
EVQLVESGGDLVKPGGSLKLSCAASGFSFSSYGMSWVRQTPDKRLEWVATISNGGGYTYY
PDSVKGRFTISRDNAKNTLYLQMSSLKSEDSAMYYCARRERYDENGFAYWGQGTLVTVSA
AKTTAPSVYPLAPVCGDTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSD
LYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKIEPR

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Germline Tools
Data Source:
Data Source V D J Exclude if warnings
NCBI Germline
V-BASE
Alignment settings:
Rank alignments by
Exclude identical hits
Search settings:
V-segment score threshold
D-segment score threshold
J-segment score threshold
Gaps:
Gap penalty

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abYmod homology modelling

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Chains
1hil_B
All Heavy
All HFR
All CDR-H
HFR1
CDR-H1
HFR2
CDR-H2
HFR3
CDR-H3
HFR4
Other Heavy
1hil_A
All Light
All LFR
All CDR-L
LFR1
CDR-L1
LFR2
CDR-L2
LFR3
CDR-L3
LFR4
Other Light
Colours
Labels
On
Off
Atoms
Main chain
All
Style
Wireframe
Ball and Stick
Spacefill
Cartoon
Backbone
Reset
Black
Reset
White

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