abYsis
  • Search
    Basic Search Sequence Search Structure Search
  • Annotate
  • Paired
  • Blast
  • Import
  • Tools
    Align Amino Acids & Regions Canonical Class Statistics Licence & Info
  • Manual

  • Summary
  • Canonical Classes
  • Germline View
  • Humanize
  • Structure
  • Library
Download
Numbering & Regions

Calculating, please wait ...

Nothing to show.
Region Sequence Details
Regions Definition:
Region Sequence Fragment Residues Length
HFR1
DVQLQESGPSLVKPSQTLSLTCSVT
1 - 25 25
CDR-H1
GDSITSD
26 - 32 7
HFR2
YWSWIRKFPGNRLEYMGYV
33 - 51 19
CDR-H2
SYSGS
52 - 56 5
HFR3
TYYNPSLKSRISITRDTSKNQYYLDLNSVTTEDTATYYCAN
57 - 97 41
CDR-H3
WDGDY
98 - 102 5
HFR4
WGQGTLVTVSA
103 - 113 11
Tail
AKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSD
LYTLSSSVTVPSSTWPSQTVTCNVAHPASSTKVDKKIVPRDCGSHHHHHH
114 - 223 110
223
Region Sequence Fragment Residues Length
HFR1
DVQLQESGPSLVKPSQTLSLTCSVT
1 - 25 25
CDR-H1
GDSITSDYWS
26 - 35 10
HFR2
WIRKFPGNRLEYMG
36 - 49 14
CDR-H2
YVSYSGSTY
50 - 58 9
HFR3
YNPSLKSRISITRDTSKNQYYLDLNSVTTEDTATYYCAN
59 - 97 39
CDR-H3
WDGDY
98 - 102 5
HFR4
WGQGTLVTVSA
103 - 113 11
Tail
AKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSD
LYTLSSSVTVPSSTWPSQTVTCNVAHPASSTKVDKKIVPRDCGSHHHHHH
114 - 223 110
223
Region Sequence Fragment Residues Length
HFR1
DVQLQESGPSLVKPSQTLSLTCSVTGDSIT
1 - 30 30
CDR-H1
SDYWS
31 - 35 5
HFR2
WIRKFPGNRLEYMG
36 - 49 14
CDR-H2
YVSYSGSTYYNPSLKS
50 - 65 16
HFR3
RISITRDTSKNQYYLDLNSVTTEDTATYYCAN
66 - 97 32
CDR-H3
WDGDY
98 - 102 5
HFR4
WGQGTLVTVSA
103 - 113 11
Tail
AKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSD
LYTLSSSVTVPSSTWPSQTVTCNVAHPASSTKVDKKIVPRDCGSHHHHHH
114 - 223 110
223
Region Sequence Fragment Residues Length
HFR1
DVQLQESGPSLVKPSQTLSLTCSVTGDSI
1 - 29 29
CDR-H1
TSDYWS
30 - 35 6
HFR2
WIRKFPGNRLE
36 - 46 11
CDR-H2
YMGYVSYSGSTY
47 - 58 12
HFR3
YNPSLKSRISITRDTSKNQYYLDLNSVTTEDTATYYC
59 - 95 37
CDR-H3
ANWDGD
96 - 101 6
HFR4
YWGQGTLVTVSA
102 - 113 12
Tail
AKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSD
LYTLSSSVTVPSSTWPSQTVTCNVAHPASSTKVDKKIVPRDCGSHHHHHH
114 - 223 110
223
Region Sequence Fragment Residues Length
HFR1
DVQLQESGPSLVKPSQTLSLTCSVT
1 - 25 25
CDR-H1
GDSITSDY
26 - 33 8
HFR2
WSWIRKFPGNRLEYMGY
34 - 50 17
CDR-H2
VSYSGST
51 - 57 7
HFR3
YYNPSLKSRISITRDTSKNQYYLDLNSVTTEDTATYYC
58 - 95 38
CDR-H3
ANWDGDY
96 - 102 7
HFR4
WGQGTLVTVSA
103 - 113 11
Tail
AKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSD
LYTLSSSVTVPSSTWPSQTVTCNVAHPASSTKVDKKIVPRDCGSHHHHHH
114 - 223 110
223
Region Definition Sequence Fragment Residues Length
HFR1 Chothia
DVQLQESGPSLVKPSQTLSLTCSVT-----
1 - 25 25
AbM
DVQLQESGPSLVKPSQTLSLTCSVT-----
1 - 25 25
Kabat
DVQLQESGPSLVKPSQTLSLTCSVTGDSIT
1 - 30 30
Contact
DVQLQESGPSLVKPSQTLSLTCSVTGDSI-
1 - 29 29
IMGT
DVQLQESGPSLVKPSQTLSLTCSVT-----
1 - 25 25
CDR-H1 Chothia
GDSITSD---
26 - 32 7
AbM
GDSITSDYWS
26 - 35 10
Kabat
-----SDYWS
31 - 35 5
Contact
----TSDYWS
30 - 35 6
IMGT
GDSITSDY--
26 - 33 8
HFR2 Chothia
YWSWIRKFPGNRLEYMGYV
33 - 51 19
AbM
---WIRKFPGNRLEYMG--
36 - 49 14
Kabat
---WIRKFPGNRLEYMG--
36 - 49 14
Contact
---WIRKFPGNRLE-----
36 - 46 11
IMGT
-WSWIRKFPGNRLEYMGY-
34 - 50 17
CDR-H2 Chothia
-----SYSGS---------
52 - 56 5
AbM
---YVSYSGSTY-------
50 - 58 9
Kabat
---YVSYSGSTYYNPSLKS
50 - 65 16
Contact
YMGYVSYSGSTY-------
47 - 58 12
IMGT
----VSYSGST--------
51 - 57 7
HFR3 Chothia
TYYNPSLKSRISITRDTSKNQYYLDLNSVTTEDTATYYCAN
57 - 97 41
AbM
--YNPSLKSRISITRDTSKNQYYLDLNSVTTEDTATYYCAN
59 - 97 39
Kabat
---------RISITRDTSKNQYYLDLNSVTTEDTATYYCAN
66 - 97 32
Contact
--YNPSLKSRISITRDTSKNQYYLDLNSVTTEDTATYYC--
59 - 95 37
IMGT
-YYNPSLKSRISITRDTSKNQYYLDLNSVTTEDTATYYC--
58 - 95 38
CDR-H3 Chothia
--WDGDY
98 - 102 5
AbM
--WDGDY
98 - 102 5
Kabat
--WDGDY
98 - 102 5
Contact
ANWDGD-
96 - 101 6
IMGT
ANWDGDY
96 - 102 7
HFR4 Chothia
-WGQGTLVTVSA
103 - 113 11
AbM
-WGQGTLVTVSA
103 - 113 11
Kabat
-WGQGTLVTVSA
103 - 113 11
Contact
YWGQGTLVTVSA
102 - 113 12
IMGT
-WGQGTLVTVSA
103 - 113 11
Humanness

Calculating, please wait ...

Accession & Annotations
Accession 6p4a_H
Source PDB  6p4a  Submitted 27-MAY-2019  Updated 16-DEC-2020
Name
HYHEL10 FAB COMPLEXED WITH HEN EGG LYSOZYME CARRYING TWO MUTATIONS (HEL2X-RIGID): R21Q AND R73E
Organism
Mus musculus
Chain Type Heavy
Pairing 6p4a_L
Identical Protein Sequences None
References
BURNETT L., SCHOFIELD P., LANGLEY B., JACKSON J., BOURNE K., WILSON E., POREBSKI T., BUCKLE M., BRINK R., GOODNOW C., CHRIST D.
'CONFORMATIONAL DIVERSITY FACILITATES ANTIBODY MUTATION TRAJECTORIES AND DISCRIMINATION BETWEEN FOREIGN AND SELF-ANTIGENS.'
PROC.NATL.ACAD.SCI.USA V. 117 22341 2020 ESSN 1091-6490
Sequences
Amino Acid Sequence:
DVQLQESGPSLVKPSQTLSLTCSVTGDSITSDYWSWIRKFPGNRLEYMGYVSYSGSTYYN
PSLKSRISITRDTSKNQYYLDLNSVTTEDTATYYCANWDGDYWGQGTLVTVSAAKTTPPS
VYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSS
VTVPSSTWPSQTVTCNVAHPASSTKVDKKIVPRDCGSHHHHHH

Calculating, please wait ...

Nothing to show.

Germline Tools
Data Source:
Data Source V D J Exclude if warnings
NCBI Germline
V-BASE
Alignment settings:
Rank alignments by
Exclude identical hits
Search settings:
V-segment score threshold
D-segment score threshold
J-segment score threshold
Gaps:
Gap penalty

Calculating, please wait ...

Nothing to show.

Calculating, please wait ...

Nothing to show.

No coordinate data for one or more of your sequences.

Use Import to load your own coordinate data where available.

No experimental structure

abYmod homology modelling

Note: following issues may prevent a model being generated:


Homology modelling failed because :-



Energy minimised    
Rapid    

Running Please wait - abYmod building model

Structure Loading, please wait ...

Chains
6p4a_H
All Heavy
All HFR
All CDR-H
HFR1
CDR-H1
HFR2
CDR-H2
HFR3
CDR-H3
HFR4
Other Heavy
6p4a_L
All Light
All LFR
All CDR-L
LFR1
CDR-L1
LFR2
CDR-L2
LFR3
CDR-L3
LFR4
Other Light
Colours
Labels
On
Off
Atoms
Main chain
All
Style
Wireframe
Ball and Stick
Spacefill
Cartoon
Backbone
Reset
Black
Reset
White

Calculating, please wait ...

Nothing to show.

Licence Required

This feature is only available in the fully-licensed version of abYsis

For further information please contact specialist distributor ebisu, or alternatively see the UCLB e-licensing website.

This public version of abYsis is made available largely through the generous support of commercial licensees.

Open Manual