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Numbering & Regions

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Region Sequence Details
Regions Definition:
Region Sequence Fragment Residues Length
HFR1
EVQLVQSGGGVVQPGRSLRLSCSSS
1 - 25 25
CDR-H1
GFIFSSY
26 - 32 7
HFR2
AMYWVRQAPGKGLEWVAII
33 - 51 19
CDR-H2
WDDGSD
52 - 57 6
HFR3
QHYADSVKGRFTISRNDSKNTLFLQMDSLRPEDTGVYFCAR
58 - 98 41
CDR-H3
DGGHGFCSSASCFGPDY
99 - 115 17
HFR4
WGQGTPVTVSS
116 - 126 11
Tail
ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPQPVTVSWNSGALTSGVHTFPAVLQSS
GLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSC
127 - 229 103
229
Region Sequence Fragment Residues Length
HFR1
EVQLVQSGGGVVQPGRSLRLSCSSS
1 - 25 25
CDR-H1
GFIFSSYAMY
26 - 35 10
HFR2
WVRQAPGKGLEWVA
36 - 49 14
CDR-H2
IIWDDGSDQH
50 - 59 10
HFR3
YADSVKGRFTISRNDSKNTLFLQMDSLRPEDTGVYFCAR
60 - 98 39
CDR-H3
DGGHGFCSSASCFGPDY
99 - 115 17
HFR4
WGQGTPVTVSS
116 - 126 11
Tail
ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPQPVTVSWNSGALTSGVHTFPAVLQSS
GLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSC
127 - 229 103
229
Region Sequence Fragment Residues Length
HFR1
EVQLVQSGGGVVQPGRSLRLSCSSSGFIFS
1 - 30 30
CDR-H1
SYAMY
31 - 35 5
HFR2
WVRQAPGKGLEWVA
36 - 49 14
CDR-H2
IIWDDGSDQHYADSVKG
50 - 66 17
HFR3
RFTISRNDSKNTLFLQMDSLRPEDTGVYFCAR
67 - 98 32
CDR-H3
DGGHGFCSSASCFGPDY
99 - 115 17
HFR4
WGQGTPVTVSS
116 - 126 11
Tail
ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPQPVTVSWNSGALTSGVHTFPAVLQSS
GLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSC
127 - 229 103
229
Region Sequence Fragment Residues Length
HFR1
EVQLVQSGGGVVQPGRSLRLSCSSSGFIF
1 - 29 29
CDR-H1
SSYAMY
30 - 35 6
HFR2
WVRQAPGKGLE
36 - 46 11
CDR-H2
WVAIIWDDGSDQH
47 - 59 13
HFR3
YADSVKGRFTISRNDSKNTLFLQMDSLRPEDTGVYFC
60 - 96 37
CDR-H3
ARDGGHGFCSSASCFGPD
97 - 114 18
HFR4
YWGQGTPVTVSS
115 - 126 12
Tail
ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPQPVTVSWNSGALTSGVHTFPAVLQSS
GLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSC
127 - 229 103
229
Region Sequence Fragment Residues Length
HFR1
EVQLVQSGGGVVQPGRSLRLSCSSS
1 - 25 25
CDR-H1
GFIFSSYA
26 - 33 8
HFR2
MYWVRQAPGKGLEWVAI
34 - 50 17
CDR-H2
IWDDGSDQ
51 - 58 8
HFR3
HYADSVKGRFTISRNDSKNTLFLQMDSLRPEDTGVYFC
59 - 96 38
CDR-H3
ARDGGHGFCSSASCFGPDY
97 - 115 19
HFR4
WGQGTPVTVSS
116 - 126 11
Tail
ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPQPVTVSWNSGALTSGVHTFPAVLQSS
GLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSC
127 - 229 103
229
Region Definition Sequence Fragment Residues Length
HFR1 Chothia
EVQLVQSGGGVVQPGRSLRLSCSSS-----
1 - 25 25
AbM
EVQLVQSGGGVVQPGRSLRLSCSSS-----
1 - 25 25
Kabat
EVQLVQSGGGVVQPGRSLRLSCSSSGFIFS
1 - 30 30
Contact
EVQLVQSGGGVVQPGRSLRLSCSSSGFIF-
1 - 29 29
IMGT
EVQLVQSGGGVVQPGRSLRLSCSSS-----
1 - 25 25
CDR-H1 Chothia
GFIFSSY---
26 - 32 7
AbM
GFIFSSYAMY
26 - 35 10
Kabat
-----SYAMY
31 - 35 5
Contact
----SSYAMY
30 - 35 6
IMGT
GFIFSSYA--
26 - 33 8
HFR2 Chothia
AMYWVRQAPGKGLEWVAII
33 - 51 19
AbM
---WVRQAPGKGLEWVA--
36 - 49 14
Kabat
---WVRQAPGKGLEWVA--
36 - 49 14
Contact
---WVRQAPGKGLE-----
36 - 46 11
IMGT
-MYWVRQAPGKGLEWVAI-
34 - 50 17
CDR-H2 Chothia
-----WDDGSD---------
52 - 57 6
AbM
---IIWDDGSDQH-------
50 - 59 10
Kabat
---IIWDDGSDQHYADSVKG
50 - 66 17
Contact
WVAIIWDDGSDQH-------
47 - 59 13
IMGT
----IWDDGSDQ--------
51 - 58 8
HFR3 Chothia
QHYADSVKGRFTISRNDSKNTLFLQMDSLRPEDTGVYFCAR
58 - 98 41
AbM
--YADSVKGRFTISRNDSKNTLFLQMDSLRPEDTGVYFCAR
60 - 98 39
Kabat
---------RFTISRNDSKNTLFLQMDSLRPEDTGVYFCAR
67 - 98 32
Contact
--YADSVKGRFTISRNDSKNTLFLQMDSLRPEDTGVYFC--
60 - 96 37
IMGT
-HYADSVKGRFTISRNDSKNTLFLQMDSLRPEDTGVYFC--
59 - 96 38
CDR-H3 Chothia
--DGGHGFCSSASCFGPDY
99 - 115 17
AbM
--DGGHGFCSSASCFGPDY
99 - 115 17
Kabat
--DGGHGFCSSASCFGPDY
99 - 115 17
Contact
ARDGGHGFCSSASCFGPD-
97 - 114 18
IMGT
ARDGGHGFCSSASCFGPDY
97 - 115 19
HFR4 Chothia
-WGQGTPVTVSS
116 - 126 11
AbM
-WGQGTPVTVSS
116 - 126 11
Kabat
-WGQGTPVTVSS
116 - 126 11
Contact
YWGQGTPVTVSS
115 - 126 12
IMGT
-WGQGTPVTVSS
116 - 126 11
Humanness

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Accession & Annotations
Accession 2fb4_H
Source PDB  2fb4  Submitted 18-APR-1989  Updated 24-FEB-2009
Name
DIR PRIMAERSTRUKTUR DES KRISTALLISIERBAREN MONOKLONALEN IMMUNOGLOBULINS IGG1 KOL. II. AMINOSAEURESEQUENZ DER L- KETTE, LAMBDA-TYP, SUBGRUPPE I (GERMAN)
Organism
Homo sapiens
Human Subgroup Heavy chain subgroup III
Chain Type Heavy
Pairing 2fb4_L
Identical Protein Sequences None
References
KRATZIN D., PALM W., STANGEL M., SCHMIDT E., FRIEDRICH J., HILSCHMANN N.
'THE PRIMARY STRUCTURE OF CRYSTALLIZABLE MONOCLONAL IMMUNOGLOBULIN IGG1 KOL. II. AMINO ACID SEQUENCE OF THE L-CHAIN, GAMMA-TYPE, SUBGROUP I'
BIOL.CHEM.HOPPE-SEYLER V. 370 263 1989 ISSN 0177-3593
Sequences
Amino Acid Sequence:
EVQLVQSGGGVVQPGRSLRLSCSSSGFIFSSYAMYWVRQAPGKGLEWVAIIWDDGSDQHY
ADSVKGRFTISRNDSKNTLFLQMDSLRPEDTGVYFCARDGGHGFCSSASCFGPDYWGQGT
PVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPQPVTVSWNSGALTSGVHTFP
AVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSC

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Germline Tools
Data Source:
Data Source V D J Exclude if warnings
NCBI Germline
V-BASE
Alignment settings:
Rank alignments by
Exclude identical hits
Search settings:
V-segment score threshold
D-segment score threshold
J-segment score threshold
Gaps:
Gap penalty

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No experimental structure

abYmod homology modelling

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Chains
2fb4_H
All Heavy
All HFR
All CDR-H
HFR1
CDR-H1
HFR2
CDR-H2
HFR3
CDR-H3
HFR4
Other Heavy
2fb4_L
All Light
All LFR
All CDR-L
LFR1
CDR-L1
LFR2
CDR-L2
LFR3
CDR-L3
LFR4
Other Light
Colours
Labels
On
Off
Atoms
Main chain
All
Style
Wireframe
Ball and Stick
Spacefill
Cartoon
Backbone
Reset
Black
Reset
White

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