abYsis

Numbering & Regions

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Region Sequence Details

Regions Definition:

Region	Sequence Fragment	Residues	Length
HFR1	VQLQQSGTELMKPGRSLKISCKTTGYIFS	1 - 29	29
CDR-H1	NYWIE	30 - 34	5
HFR2	WVKQRPGHGLEWIG	35 - 48	14
CDR-H2	KILPGGGSNTYNDKFKG	49 - 65	17
HFR3	KATFTADTSSNIAYMQLSSLTSEDSAVYYCAR	66 - 97	32
CDR-H3	GEDYYAYWYVLDY	98 - 110	13
HFR4	WGQGTTVTVSS	111 - 121	11
Tail	GGGGS	122 - 126	5
			126

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	VQLQQSGTELMKPGRSLKISCKTT-----	1 - 24	24
	AbM	VQLQQSGTELMKPGRSLKISCKTT-----	1 - 24	24
	Kabat	VQLQQSGTELMKPGRSLKISCKTTGYIFS	1 - 29	29
	Contact	VQLQQSGTELMKPGRSLKISCKTTGYIF-	1 - 28	28
	IMGT	VQLQQSGTELMKPGRSLKISCKTT-----	1 - 24	24
CDR-H1	Chothia	GYIFSNY---	25 - 31	7
	AbM	GYIFSNYWIE	25 - 34	10
	Kabat	-----NYWIE	30 - 34	5
	Contact	----SNYWIE	29 - 34	6
	IMGT	GYIFSNYW--	25 - 32	8
HFR2	Chothia	WIEWVKQRPGHGLEWIGKI	32 - 50	19
	AbM	---WVKQRPGHGLEWIG--	35 - 48	14
	Kabat	---WVKQRPGHGLEWIG--	35 - 48	14
	Contact	---WVKQRPGHGLE-----	35 - 45	11
	IMGT	-IEWVKQRPGHGLEWIGK-	33 - 49	17
CDR-H2	Chothia	-----LPGGGS---------	51 - 56	6
	AbM	---KILPGGGSNT-------	49 - 58	10
	Kabat	---KILPGGGSNTYNDKFKG	49 - 65	17
	Contact	WIGKILPGGGSNT-------	46 - 58	13
	IMGT	----ILPGGGSN--------	50 - 57	8
HFR3	Chothia	NTYNDKFKGKATFTADTSSNIAYMQLSSLTSEDSAVYYCAR	57 - 97	41
	AbM	--YNDKFKGKATFTADTSSNIAYMQLSSLTSEDSAVYYCAR	59 - 97	39
	Kabat	---------KATFTADTSSNIAYMQLSSLTSEDSAVYYCAR	66 - 97	32
	Contact	--YNDKFKGKATFTADTSSNIAYMQLSSLTSEDSAVYYC--	59 - 95	37
	IMGT	-TYNDKFKGKATFTADTSSNIAYMQLSSLTSEDSAVYYC--	58 - 95	38
CDR-H3	Chothia	--GEDYYAYWYVLDY	98 - 110	13
	AbM	--GEDYYAYWYVLDY	98 - 110	13
	Kabat	--GEDYYAYWYVLDY	98 - 110	13
	Contact	ARGEDYYAYWYVLD-	96 - 109	14
	IMGT	ARGEDYYAYWYVLDY	96 - 110	15
HFR4	Chothia	-WGQGTTVTVSS	111 - 121	11
	AbM	-WGQGTTVTVSS	111 - 121	11
	Kabat	-WGQGTTVTVSS	111 - 121	11
	Contact	YWGQGTTVTVSS	110 - 121	12
	IMGT	-WGQGTTVTVSS	111 - 121	11

Humanness

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Accession & Annotations

Accession	1lmk_G_i
Source	PDB 1lmk Submitted 29-AUG-1994 Updated 24-FEB-2009
Name	THE STRUCTURE OF A BIVALENT DIABODY
Organism	Mus musculus
Chain Type	Heavy
Pairing	1lmk_E_ii
Identical Protein Sequences	PDB: 1lmk_A_i 1lmk_C_i 1lmk_E_i
References	PERISIC O., WEBB A., HOLLIGER P., WINTER G., WILLIAMS L. 'CRYSTAL STRUCTURE OF A DIABODY, A BIVALENT ANTIBODY FRAGMENT.' STRUCTURE V. 2 1217 1994 ISSN 0969-2126

Sequences

Amino Acid Sequence:

VQLQQSGTELMKPGRSLKISCKTTGYIFSNYWIEWVKQRPGHGLEWIGKILPGGGSNTYN
DKFKGKATFTADTSSNIAYMQLSSLTSEDSAVYYCARGEDYYAYWYVLDYWGQGTTVTVS
SGGGGS