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Numbering & Regions

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Region Sequence Details
Regions Definition:
Region Sequence Fragment Residues Length
HFR1
DVQLQQSGPELEKPGASVKISCKAS
1 - 25 25
CDR-H1
GFSLPGH
26 - 32 7
HFR2
NINWIVQRNGKSLEWIGNI
33 - 51 19
CDR-H2
DPYYGG
52 - 57 6
HFR3
TNFNPKFKGKATLTVDKSSSTLYMHLTSLQSEDSAVYYCAR
58 - 98 41
CDR-H3
RRDGNYGFTY
99 - 108 10
HFR4
WGQGTLVTVSA
109 - 119 11
Tail
AKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSD
LYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKI
120 - 216 97
216
Region Sequence Fragment Residues Length
HFR1
DVQLQQSGPELEKPGASVKISCKAS
1 - 25 25
CDR-H1
GFSLPGHNIN
26 - 35 10
HFR2
WIVQRNGKSLEWIG
36 - 49 14
CDR-H2
NIDPYYGGTN
50 - 59 10
HFR3
FNPKFKGKATLTVDKSSSTLYMHLTSLQSEDSAVYYCAR
60 - 98 39
CDR-H3
RRDGNYGFTY
99 - 108 10
HFR4
WGQGTLVTVSA
109 - 119 11
Tail
AKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSD
LYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKI
120 - 216 97
216
Region Sequence Fragment Residues Length
HFR1
DVQLQQSGPELEKPGASVKISCKASGFSLP
1 - 30 30
CDR-H1
GHNIN
31 - 35 5
HFR2
WIVQRNGKSLEWIG
36 - 49 14
CDR-H2
NIDPYYGGTNFNPKFKG
50 - 66 17
HFR3
KATLTVDKSSSTLYMHLTSLQSEDSAVYYCAR
67 - 98 32
CDR-H3
RRDGNYGFTY
99 - 108 10
HFR4
WGQGTLVTVSA
109 - 119 11
Tail
AKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSD
LYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKI
120 - 216 97
216
Region Sequence Fragment Residues Length
HFR1
DVQLQQSGPELEKPGASVKISCKASGFSL
1 - 29 29
CDR-H1
PGHNIN
30 - 35 6
HFR2
WIVQRNGKSLE
36 - 46 11
CDR-H2
WIGNIDPYYGGTN
47 - 59 13
HFR3
FNPKFKGKATLTVDKSSSTLYMHLTSLQSEDSAVYYC
60 - 96 37
CDR-H3
ARRRDGNYGFT
97 - 107 11
HFR4
YWGQGTLVTVSA
108 - 119 12
Tail
AKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSD
LYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKI
120 - 216 97
216
Region Sequence Fragment Residues Length
HFR1
DVQLQQSGPELEKPGASVKISCKAS
1 - 25 25
CDR-H1
GFSLPGHN
26 - 33 8
HFR2
INWIVQRNGKSLEWIGN
34 - 50 17
CDR-H2
IDPYYGGT
51 - 58 8
HFR3
NFNPKFKGKATLTVDKSSSTLYMHLTSLQSEDSAVYYC
59 - 96 38
CDR-H3
ARRRDGNYGFTY
97 - 108 12
HFR4
WGQGTLVTVSA
109 - 119 11
Tail
AKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSD
LYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKI
120 - 216 97
216
Region Definition Sequence Fragment Residues Length
HFR1 Chothia
DVQLQQSGPELEKPGASVKISCKAS-----
1 - 25 25
AbM
DVQLQQSGPELEKPGASVKISCKAS-----
1 - 25 25
Kabat
DVQLQQSGPELEKPGASVKISCKASGFSLP
1 - 30 30
Contact
DVQLQQSGPELEKPGASVKISCKASGFSL-
1 - 29 29
IMGT
DVQLQQSGPELEKPGASVKISCKAS-----
1 - 25 25
CDR-H1 Chothia
GFSLPGH---
26 - 32 7
AbM
GFSLPGHNIN
26 - 35 10
Kabat
-----GHNIN
31 - 35 5
Contact
----PGHNIN
30 - 35 6
IMGT
GFSLPGHN--
26 - 33 8
HFR2 Chothia
NINWIVQRNGKSLEWIGNI
33 - 51 19
AbM
---WIVQRNGKSLEWIG--
36 - 49 14
Kabat
---WIVQRNGKSLEWIG--
36 - 49 14
Contact
---WIVQRNGKSLE-----
36 - 46 11
IMGT
-INWIVQRNGKSLEWIGN-
34 - 50 17
CDR-H2 Chothia
-----DPYYGG---------
52 - 57 6
AbM
---NIDPYYGGTN-------
50 - 59 10
Kabat
---NIDPYYGGTNFNPKFKG
50 - 66 17
Contact
WIGNIDPYYGGTN-------
47 - 59 13
IMGT
----IDPYYGGT--------
51 - 58 8
HFR3 Chothia
TNFNPKFKGKATLTVDKSSSTLYMHLTSLQSEDSAVYYCAR
58 - 98 41
AbM
--FNPKFKGKATLTVDKSSSTLYMHLTSLQSEDSAVYYCAR
60 - 98 39
Kabat
---------KATLTVDKSSSTLYMHLTSLQSEDSAVYYCAR
67 - 98 32
Contact
--FNPKFKGKATLTVDKSSSTLYMHLTSLQSEDSAVYYC--
60 - 96 37
IMGT
-NFNPKFKGKATLTVDKSSSTLYMHLTSLQSEDSAVYYC--
59 - 96 38
CDR-H3 Chothia
--RRDGNYGFTY
99 - 108 10
AbM
--RRDGNYGFTY
99 - 108 10
Kabat
--RRDGNYGFTY
99 - 108 10
Contact
ARRRDGNYGFT-
97 - 107 11
IMGT
ARRRDGNYGFTY
97 - 108 12
HFR4 Chothia
-WGQGTLVTVSA
109 - 119 11
AbM
-WGQGTLVTVSA
109 - 119 11
Kabat
-WGQGTLVTVSA
109 - 119 11
Contact
YWGQGTLVTVSA
108 - 119 12
IMGT
-WGQGTLVTVSA
109 - 119 11
Humanness

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Accession & Annotations
Accession 1fig_H
Source PDB  1fig  Submitted 07-JAN-1994  Updated 25-AUG-2009
Name
ROUTES TO CATALYSIS: STRUCTURE OF A CATALYTIC ANTIBODY AND COMPARISON WITH ITS NATURAL COUNTERPART
Organism
Mus musculus
Chain Type Heavy
Pairing 1fig_L
Identical Protein Sequences None
References
HAYNES R., STURA A., HILVERT D., WILSON A.
'ROUTES TO CATALYSIS: STRUCTURE OF A CATALYTIC ANTIBODY AND COMPARISON WITH ITS NATURAL COUNTERPART.'
SCIENCE V. 263 646 1994 ISSN 0036-8075
Sequences
Amino Acid Sequence:
DVQLQQSGPELEKPGASVKISCKASGFSLPGHNINWIVQRNGKSLEWIGNIDPYYGGTNF
NPKFKGKATLTVDKSSSTLYMHLTSLQSEDSAVYYCARRRDGNYGFTYWGQGTLVTVSAA
KTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDL
YTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKI

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Germline Tools
Data Source:
Data Source V D J Exclude if warnings
NCBI Germline
V-BASE
Alignment settings:
Rank alignments by
Exclude identical hits
Search settings:
V-segment score threshold
D-segment score threshold
J-segment score threshold
Gaps:
Gap penalty

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No experimental structure

abYmod homology modelling

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Chains
1fig_H
All Heavy
All HFR
All CDR-H
HFR1
CDR-H1
HFR2
CDR-H2
HFR3
CDR-H3
HFR4
Other Heavy
1fig_L
All Light
All LFR
All CDR-L
LFR1
CDR-L1
LFR2
CDR-L2
LFR3
CDR-L3
LFR4
Other Light
Colours
Labels
On
Off
Atoms
Main chain
All
Style
Wireframe
Ball and Stick
Spacefill
Cartoon
Backbone
Reset
Black
Reset
White

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