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Numbering & Regions

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Region Sequence Details
Regions Definition:
Region Sequence Fragment Residues Length
HFR1
EVKLVESGGGLVQPGGSLKLSCATS
1 - 25 25
CDR-H1
GFTFSDY
26 - 32 7
HFR2
YMYWVRQNSEKRLEWVAFI
33 - 51 19
CDR-H2
SNGGGS
52 - 57 6
HFR3
AFYADIVKGRFTISRDNAKNTLYLQMSRLKSEDTAMYYCTR
58 - 98 41
CDR-H3
HTLYDTLYGNYPVWFAD
99 - 115 17
HFR4
WGQGTLVTVSA
116 - 126 11
Tail
AKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSD
LYTLSSSVTVPSSSRPSETVTCNVAHPASSTKVDKKIVPRDC
127 - 228 102
228
Region Sequence Fragment Residues Length
HFR1
EVKLVESGGGLVQPGGSLKLSCATS
1 - 25 25
CDR-H1
GFTFSDYYMY
26 - 35 10
HFR2
WVRQNSEKRLEWVA
36 - 49 14
CDR-H2
FISNGGGSAF
50 - 59 10
HFR3
YADIVKGRFTISRDNAKNTLYLQMSRLKSEDTAMYYCTR
60 - 98 39
CDR-H3
HTLYDTLYGNYPVWFAD
99 - 115 17
HFR4
WGQGTLVTVSA
116 - 126 11
Tail
AKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSD
LYTLSSSVTVPSSSRPSETVTCNVAHPASSTKVDKKIVPRDC
127 - 228 102
228
Region Sequence Fragment Residues Length
HFR1
EVKLVESGGGLVQPGGSLKLSCATSGFTFS
1 - 30 30
CDR-H1
DYYMY
31 - 35 5
HFR2
WVRQNSEKRLEWVA
36 - 49 14
CDR-H2
FISNGGGSAFYADIVKG
50 - 66 17
HFR3
RFTISRDNAKNTLYLQMSRLKSEDTAMYYCTR
67 - 98 32
CDR-H3
HTLYDTLYGNYPVWFAD
99 - 115 17
HFR4
WGQGTLVTVSA
116 - 126 11
Tail
AKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSD
LYTLSSSVTVPSSSRPSETVTCNVAHPASSTKVDKKIVPRDC
127 - 228 102
228
Region Sequence Fragment Residues Length
HFR1
EVKLVESGGGLVQPGGSLKLSCATSGFTF
1 - 29 29
CDR-H1
SDYYMY
30 - 35 6
HFR2
WVRQNSEKRLE
36 - 46 11
CDR-H2
WVAFISNGGGSAF
47 - 59 13
HFR3
YADIVKGRFTISRDNAKNTLYLQMSRLKSEDTAMYYC
60 - 96 37
CDR-H3
TRHTLYDTLYGNYPVWFA
97 - 114 18
HFR4
DWGQGTLVTVSA
115 - 126 12
Tail
AKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSD
LYTLSSSVTVPSSSRPSETVTCNVAHPASSTKVDKKIVPRDC
127 - 228 102
228
Region Sequence Fragment Residues Length
HFR1
EVKLVESGGGLVQPGGSLKLSCATS
1 - 25 25
CDR-H1
GFTFSDYY
26 - 33 8
HFR2
MYWVRQNSEKRLEWVAF
34 - 50 17
CDR-H2
ISNGGGSA
51 - 58 8
HFR3
FYADIVKGRFTISRDNAKNTLYLQMSRLKSEDTAMYYC
59 - 96 38
CDR-H3
TRHTLYDTLYGNYPVWFAD
97 - 115 19
HFR4
WGQGTLVTVSA
116 - 126 11
Tail
AKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSD
LYTLSSSVTVPSSSRPSETVTCNVAHPASSTKVDKKIVPRDC
127 - 228 102
228
Region Definition Sequence Fragment Residues Length
HFR1 Chothia
EVKLVESGGGLVQPGGSLKLSCATS-----
1 - 25 25
AbM
EVKLVESGGGLVQPGGSLKLSCATS-----
1 - 25 25
Kabat
EVKLVESGGGLVQPGGSLKLSCATSGFTFS
1 - 30 30
Contact
EVKLVESGGGLVQPGGSLKLSCATSGFTF-
1 - 29 29
IMGT
EVKLVESGGGLVQPGGSLKLSCATS-----
1 - 25 25
CDR-H1 Chothia
GFTFSDY---
26 - 32 7
AbM
GFTFSDYYMY
26 - 35 10
Kabat
-----DYYMY
31 - 35 5
Contact
----SDYYMY
30 - 35 6
IMGT
GFTFSDYY--
26 - 33 8
HFR2 Chothia
YMYWVRQNSEKRLEWVAFI
33 - 51 19
AbM
---WVRQNSEKRLEWVA--
36 - 49 14
Kabat
---WVRQNSEKRLEWVA--
36 - 49 14
Contact
---WVRQNSEKRLE-----
36 - 46 11
IMGT
-MYWVRQNSEKRLEWVAF-
34 - 50 17
CDR-H2 Chothia
-----SNGGGS---------
52 - 57 6
AbM
---FISNGGGSAF-------
50 - 59 10
Kabat
---FISNGGGSAFYADIVKG
50 - 66 17
Contact
WVAFISNGGGSAF-------
47 - 59 13
IMGT
----ISNGGGSA--------
51 - 58 8
HFR3 Chothia
AFYADIVKGRFTISRDNAKNTLYLQMSRLKSEDTAMYYCTR
58 - 98 41
AbM
--YADIVKGRFTISRDNAKNTLYLQMSRLKSEDTAMYYCTR
60 - 98 39
Kabat
---------RFTISRDNAKNTLYLQMSRLKSEDTAMYYCTR
67 - 98 32
Contact
--YADIVKGRFTISRDNAKNTLYLQMSRLKSEDTAMYYC--
60 - 96 37
IMGT
-FYADIVKGRFTISRDNAKNTLYLQMSRLKSEDTAMYYC--
59 - 96 38
CDR-H3 Chothia
--HTLYDTLYGNYPVWFAD
99 - 115 17
AbM
--HTLYDTLYGNYPVWFAD
99 - 115 17
Kabat
--HTLYDTLYGNYPVWFAD
99 - 115 17
Contact
TRHTLYDTLYGNYPVWFA-
97 - 114 18
IMGT
TRHTLYDTLYGNYPVWFAD
97 - 115 19
HFR4 Chothia
-WGQGTLVTVSA
116 - 126 11
AbM
-WGQGTLVTVSA
116 - 126 11
Kabat
-WGQGTLVTVSA
116 - 126 11
Contact
DWGQGTLVTVSA
115 - 126 12
IMGT
-WGQGTLVTVSA
116 - 126 11
Humanness

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Accession & Annotations
Accession 1ikf_H
Source PDB  1ikf  Submitted 09-DEC-1993  Updated 27-JUL-2011
Name
A CONFORMATION OF CYCLOSPORIN A IN AQUEOUS ENVIRONMENT REVEALED BY THE X-RAY STRUCTURE OF A CYCLOSPORIN-FAB COMPLEX
Organism
Homo sapiens
Human Subgroup Heavy chain subgroup III
Chain Type Heavy
Pairing 1ikf_L
Identical Protein Sequences None
References
ALTSCHUH D., VIX O., REES B., THIERRY C.
'A CONFORMATION OF CYCLOSPORIN A IN AQUEOUS ENVIRONMENT REVEALED BY THE X-RAY STRUCTURE OF A CYCLOSPORIN-FAB COMPLEX.'
SCIENCE V. 256 92 1992 ISSN 0036-8075
Sequences
Amino Acid Sequence:
EVKLVESGGGLVQPGGSLKLSCATSGFTFSDYYMYWVRQNSEKRLEWVAFISNGGGSAFY
ADIVKGRFTISRDNAKNTLYLQMSRLKSEDTAMYYCTRHTLYDTLYGNYPVWFADWGQGT
LVTVSAAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFP
AVLQSDLYTLSSSVTVPSSSRPSETVTCNVAHPASSTKVDKKIVPRDC

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Germline Tools
Data Source:
Data Source V D J Exclude if warnings
NCBI Germline
V-BASE
Alignment settings:
Rank alignments by
Exclude identical hits
Search settings:
V-segment score threshold
D-segment score threshold
J-segment score threshold
Gaps:
Gap penalty

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No experimental structure

abYmod homology modelling

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Chains
1ikf_H
All Heavy
All HFR
All CDR-H
HFR1
CDR-H1
HFR2
CDR-H2
HFR3
CDR-H3
HFR4
Other Heavy
1ikf_L
All Light
All LFR
All CDR-L
LFR1
CDR-L1
LFR2
CDR-L2
LFR3
CDR-L3
LFR4
Other Light
Colours
Labels
On
Off
Atoms
Main chain
All
Style
Wireframe
Ball and Stick
Spacefill
Cartoon
Backbone
Reset
Black
Reset
White

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