abYsis

Numbering & Regions

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Region Sequence Details

Regions Definition:

Region	Sequence Fragment	Residues	Length
HFR1	AVKLVQAGGGVVQPGRSLRLSCIASGFTFS	1 - 30	30
CDR-H1	NYGMH	31 - 35	5
HFR2	WVRQAPGKGLEWVA	36 - 49	14
CDR-H2	VIWYNGSRTYYGDSVKG	50 - 66	17
HFR3	RFTISRDNSKRTLYMQMNSLRTEDTAVYYCAR	67 - 98	32
CDR-H3	DPDILTAFSFDY	99 - 110	12
HFR4	WGQGVLVTVSS	111 - 121	11
Tail	ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSS GLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC	122 - 224	103
			224

Humanness

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Accession & Annotations

Accession	8fab_D
Source	PDB 8fab Submitted 23-MAR-1992 Updated 24-FEB-2009
Name	CRYSTAL STRUCTURE OF THE FAB FRAGMENT FROM THE HUMAN MYELOMA IMMUNOGLOBULIN IGG HIL AT 1.8 ANGSTROMS RESOLUTION
Organism	Homo sapiens
Human Subgroup	Heavy chain subgroup III
Chain Type	Heavy
Pairing	8fab_C
Identical Protein Sequences	PDB: 8fab_B
References	STRONG K., CAMPBELL R., ROSE R., PETSKO A., SHARON J., MARGOLIES N. 'THREE-DIMENSIONAL STRUCTURE OF MURINE ANTI-P-AZOPHENYLARSONATE FAB 36-71. 1. X-RAY CRYSTALLOGRAPHY, SITE-DIRECTED MUTAGENESIS, AND MODELING OF THE COMPLEX WITH HAPTEN.' BIOCHEMISTRY V. 30 3739 1991 ISSN 0006-2960

Sequences

Amino Acid Sequence:

AVKLVQAGGGVVQPGRSLRLSCIASGFTFSNYGMHWVRQAPGKGLEWVAVIWYNGSRTYY
GDSVKGRFTISRDNSKRTLYMQMNSLRTEDTAVYYCARDPDILTAFSFDYWGQGVLVTVS
SASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQS
SGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC

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